Creatine Monohydrate: Benefits from Clinical Research

Creatine Monohydrate: Benefits from Clinical Research

Daniel Casas

Creatine monohydrate is a widely researched and well-established supplement that has been shown to offer several benefits, particularly for athletes and individuals involved in high-intensity, short-duration activities. Here are some of the key benefits of creatine monohydrate, along with links to reference studies:

- Improved Muscle Performance:

Creatine is known to enhance muscle strength and power, making it a popular choice for athletes and bodybuilders.

Reference Study: Rawson, E. S., & Volek, J. S. (2003). Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. Journal of Strength and Conditioning Research, 17(4), 822-831. Link

- Increased Muscle Mass:

Creatine can lead to an increase in muscle size and may help promote lean muscle mass.

Reference Study: Chilibeck, P. D., Stride, D., Farthing, J. P., & Burke, D. G. (2004). Effect of creatine ingestion after exercise on muscle thickness in males and females. Medicine and Science in Sports and Exercise, 36(10), 1781-1788. Link

- Enhanced Exercise Capacity:

Creatine supplementation can improve endurance and performance during high-intensity, short-duration activities. 

Reference Study: Kreider, R. B., et al. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14(1), 18. Link

- Brain Health and Cognitive Function:

Some research suggests that creatine may have cognitive benefits, including improved memory and mental clarity. 

Reference Study: Rae, C., et al. (2003). Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial. Proceedings of the Royal Society of London. Series B: Biological Sciences, 270(1529), 2147-2150. Link

- Recovery and Muscle Repair:

Creatine may help reduce muscle damage and inflammation, leading to faster recovery after intense exercise. 

Reference Study: Santos, R. V., et al. (2004). The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30 km race. Life Sciences, 75(16), 1917-1924. Link

- Therapeutic Uses:

Creatine has shown promise in various medical conditions, such as neuromuscular diseases, where it may help improve muscle function. 

Reference Study: Tarnopolsky, M. A., et al. (2004). Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Neurology, 62(10), 1771-1777. Link

It’s important to note that while creatine monohydrate has many potential benefits, individual responses may vary. Additionally, always consult with a healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions.


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